Abstract: Choroidal neovascularization (CNV) is a common pathological endpoint of various choroidal retinal diseases and the main cause of irreversible visual impairment in humans. The formation of CNV is a very complex pathophysiological process involving a variety of structural cells, inflammatory cells and inflammatory factors, and is related to local chronic inflammation of the retina. Studies have shown that interleukins (ILs), as a large family of inflammatory cytokines, participate in the occurrence and development of CNV by regulating the expression of pro-angiogenic and anti-angiogenic factors in different immune microenvironments, and regulating the generation and function of ILs may serve as potential therapeutic targets. (Int Rev Ophthalmol, 2023, 47: 84-91)

Key words: interleukins, choroidal neovascularization